Gene Explorer

Description

Simulate gene expression fast and easy. Gene Explorer is an interactive simulation of gene expression that allows the user to:
1. Explore a sample gene:
* Explore the correspondence between DNA, pre-mRNA, mature mRNA, and protein
* Map the functional elements of a gene.
2. Create mutations in a gene and explore their effects.
3. Design a gene of their own and see how it is expressed.The figure above shows the Gene Explorer display:
1. The DNA strands with base-pair 62 highlighted.
* The user can scroll to select other bases with the arrow keys.
* The user can edit the DNA sequence to produce mutations.
2. The pre-mRNA extending from the promoter to the terminator. Exons and introns are shown in color. 3. The mRNA base corresponding to base 62 in the DNA is highlighted.
4. The mature mRNA spliced according to the splice signals in the pre-mRNA. Start and stop codons are underlined. The mRNA base corresponding to DNA base 62 is highlighted.
5. The protein with its N and C termini shown. The amino acid whose codon includes the mRNA encoded by DNA base 62 is highlighted.Any changes to the DNA are immediately reflected in changes in the other sequences as appropriate. The program computes the different sequences as follows:
1. Starts with a DNA sequence.
2. Finds the promoter (TATAA).
3. Transcribes the pre-mRNA until it reaches a terminator (GGGGG).
4. Removes the introns from the pre-mRNA (GUGCG......CAAAG).
5. Adds a poly A tail.
6. Translates the mature mRNA from the first AUG to the stop codon.Requirements:
* Java

Published By:intro.bio.umb.edu

License Type:Freeware

Date Added:15 October, 2012

Version:1.3

Price:Free

Downloads:0

Size:70.8 KB

Platform: Macintosh

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